Letrozole is an aromatase inhibitor, meaning that it blocks an enzyme responsible for a key step in the formation of estrogens. More specifically, the enzyme aromatase is responsible for the conversion of androgens (e.g., testosterone) into estrogens. Letrozole inhibits this process, which reduces the amount of estrogen in the body.
Athletes who abuse anabolic steroids might use an aromatase inhibitor like letrozole to prevent the formation of estrogens, and therefore reduce or prevent the unwanted and feminizing effects of anabolic steroid use. These side effects include male breast development (gynecomastia), water retention, and belly fat. In addition, male athletes may use abuse aromatase inhibitors like letrozole to boost their own natural levels of testosterone by preventing its breakdown.
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